node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
boc | disp1 | ENSDARP00000098383 | ENSDARP00000065230 | BOC cell adhesion-associated, oncogene-regulated. | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | 0.532 |
boc | dzip1 | ENSDARP00000098383 | ENSDARP00000105423 | BOC cell adhesion-associated, oncogene-regulated. | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | 0.561 |
boc | gli1 | ENSDARP00000098383 | ENSDARP00000129932 | BOC cell adhesion-associated, oncogene-regulated. | GLI family zinc finger 1. | 0.486 |
boc | gli2a | ENSDARP00000098383 | ENSDARP00000010693 | BOC cell adhesion-associated, oncogene-regulated. | GLI family zinc finger 2a. | 0.596 |
boc | kif7 | ENSDARP00000098383 | ENSDARP00000041576 | BOC cell adhesion-associated, oncogene-regulated. | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. | 0.485 |
boc | smo | ENSDARP00000098383 | ENSDARP00000013486 | BOC cell adhesion-associated, oncogene-regulated. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.762 |
dazap2 | dzip1 | ENSDARP00000004236 | ENSDARP00000105423 | DAZ-associated protein 2. | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | 0.803 |
disp1 | boc | ENSDARP00000065230 | ENSDARP00000098383 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | BOC cell adhesion-associated, oncogene-regulated. | 0.532 |
disp1 | dzip1 | ENSDARP00000065230 | ENSDARP00000105423 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | 0.774 |
disp1 | gli1 | ENSDARP00000065230 | ENSDARP00000129932 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | GLI family zinc finger 1. | 0.415 |
disp1 | gli2a | ENSDARP00000065230 | ENSDARP00000010693 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | GLI family zinc finger 2a. | 0.644 |
disp1 | kif7 | ENSDARP00000065230 | ENSDARP00000041576 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. | 0.425 |
disp1 | smo | ENSDARP00000065230 | ENSDARP00000013486 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.705 |
dzip1 | boc | ENSDARP00000105423 | ENSDARP00000098383 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | BOC cell adhesion-associated, oncogene-regulated. | 0.561 |
dzip1 | dazap2 | ENSDARP00000105423 | ENSDARP00000004236 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | DAZ-associated protein 2. | 0.803 |
dzip1 | disp1 | ENSDARP00000105423 | ENSDARP00000065230 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | 0.774 |
dzip1 | gli1 | ENSDARP00000105423 | ENSDARP00000129932 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | GLI family zinc finger 1. | 0.580 |
dzip1 | gli2a | ENSDARP00000105423 | ENSDARP00000010693 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | GLI family zinc finger 2a. | 0.824 |
dzip1 | gli3 | ENSDARP00000105423 | ENSDARP00000058991 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | GLI family zinc finger 3. | 0.588 |
dzip1 | ift88 | ENSDARP00000105423 | ENSDARP00000034047 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | Intraflagellar transport 88 homolog. | 0.488 |