node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
atoh7 | isl1 | ENSDARP00000092102 | ENSDARP00000012903 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.773 |
atoh7 | lhx1a | ENSDARP00000092102 | ENSDARP00000021069 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | 0.412 |
atoh7 | onecutl | ENSDARP00000092102 | ENSDARP00000124289 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | One cut domain family member. | 0.654 |
atoh7 | pou4f2 | ENSDARP00000092102 | ENSDARP00000111629 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | POU domain protein. | 0.884 |
atoh7 | ptf1a | ENSDARP00000092102 | ENSDARP00000011265 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.427 |
atoh7 | vsx2 | ENSDARP00000092102 | ENSDARP00000038309 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. | 0.905 |
fam214a | onecutl | ENSDARP00000107518 | ENSDARP00000124289 | Protein FAM214A. | One cut domain family member. | 0.663 |
foxa2 | isl1 | ENSDARP00000007827 | ENSDARP00000012903 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.719 |
foxa2 | lhx1a | ENSDARP00000007827 | ENSDARP00000021069 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | 0.621 |
foxa2 | neurog3 | ENSDARP00000007827 | ENSDARP00000106489 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Neurog3 protein. | 0.686 |
foxa2 | onecutl | ENSDARP00000007827 | ENSDARP00000124289 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | One cut domain family member. | 0.587 |
foxa2 | ptf1a | ENSDARP00000007827 | ENSDARP00000011265 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.616 |
isl1 | atoh7 | ENSDARP00000012903 | ENSDARP00000092102 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | 0.773 |
isl1 | foxa2 | ENSDARP00000012903 | ENSDARP00000007827 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | 0.719 |
isl1 | neurog3 | ENSDARP00000012903 | ENSDARP00000106489 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | Neurog3 protein. | 0.809 |
isl1 | onecutl | ENSDARP00000012903 | ENSDARP00000124289 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | One cut domain family member. | 0.622 |
isl1 | pou4f2 | ENSDARP00000012903 | ENSDARP00000111629 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | POU domain protein. | 0.869 |
isl1 | ptf1a | ENSDARP00000012903 | ENSDARP00000011265 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.794 |
isl1 | vsx2 | ENSDARP00000012903 | ENSDARP00000038309 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. | 0.853 |
lhx1a | atoh7 | ENSDARP00000021069 | ENSDARP00000092102 | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. | 0.412 |