STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpc1aSecreted glypican-1; Cell surface proteoglycan that bears heparan sulfate; Belongs to the glypican family. (563 aa)    
Predicted Functional Partners:
add3a
Adducin 3 (gamma) a.
      
 0.807
Sdc3
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
     
 0.800
slit2
Slit homolog 2 (Drosophila).
   
 0.726
hs6st1a
Heparan-sulfate 6-O-sulfotransferase 1-A; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
     
 0.672
tdgf1
Teratocarcinoma-derived growth factor 1.
    
 
 0.670
ext2
Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family.
     
 0.660
gpc3
Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway (By similarity). Positively regulates the canonical and non-canonical Wnt signaling pathways (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development (By sim [...]
    
0.643
srgn
Serglycin.
      
 0.641
hs6st2
Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis.
     
 0.625
xpnpep1
X-prolyl aminopeptidase (Aminopeptidase P) 1, Soluble; Belongs to the peptidase M24B family.
      
 0.619
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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