STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fam83dProtein FAM83D; May regulate cell proliferation, growth, migration and epithelial to mesenchymal transition. May also be important for proper chromosome congression and alignment during mitosis. Belongs to the FAM83 family. (534 aa)    
Predicted Functional Partners:
csnk1a1
Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.
   
 
 0.828
ubxn1
UBX domain-containing protein 1; Ubiquitin-binding protein that specifically binds 'Lys-6'- linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity).
   
  
 0.575
kif4
Kinesin family member 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.571
tpx2
TPX2 microtubule nucleation factor.
   
  
 0.566
dlgap5
Discs, large (Drosophila) homolog-associated protein 5.
   
  
 0.544
tuba8l3
Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
      
 0.544
nek2
NIMA (Never in mitosis gene a)-related kinase 2.
   
  
 0.522
cdca8
Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity).
   
  
 0.505
pbk
Lymphokine-activated killer T-cell-originated protein kinase homolog.
   
 
 0.503
cdc20
Cell division cycle 20 homolog.
   
  
 0.477
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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