node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC799520 | lats1 | ENSDARP00000113517 | ENSDARP00000027561 | Si:dkey-266m15.5. | LATS, large tumor suppressor, homolog 1 (Drosophila). | 0.704 |
LOC799520 | lats2 | ENSDARP00000113517 | ENSDARP00000114142 | Si:dkey-266m15.5. | Large tumor suppressor kinase 2. | 0.704 |
LOC799520 | mtus1a | ENSDARP00000113517 | ENSDARP00000096667 | Si:dkey-266m15.5. | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | 0.603 |
buc | mtus1a | ENSDARP00000125536 | ENSDARP00000096667 | Bucky ball; Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis. Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains. Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body. Interaction of BUC protein and mRNA with rbpms2 and d [...] | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | 0.743 |
buc | setdb1a | ENSDARP00000125536 | ENSDARP00000082769 | Bucky ball; Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis. Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains. Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body. Interaction of BUC protein and mRNA with rbpms2 and d [...] | Histone-lysine N-methyltransferase SETDB1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-re [...] | 0.743 |
buc | tdrd1 | ENSDARP00000125536 | ENSDARP00000127267 | Bucky ball; Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis. Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains. Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body. Interaction of BUC protein and mRNA with rbpms2 and d [...] | Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of corr [...] | 0.470 |
lats1 | LOC799520 | ENSDARP00000027561 | ENSDARP00000113517 | LATS, large tumor suppressor, homolog 1 (Drosophila). | Si:dkey-266m15.5. | 0.704 |
lats1 | mtus1a | ENSDARP00000027561 | ENSDARP00000096667 | LATS, large tumor suppressor, homolog 1 (Drosophila). | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | 0.603 |
lats1 | sav1 | ENSDARP00000027561 | ENSDARP00000025090 | LATS, large tumor suppressor, homolog 1 (Drosophila). | Salvador family WW domain-containing protein 1. | 0.993 |
lats2 | LOC799520 | ENSDARP00000114142 | ENSDARP00000113517 | Large tumor suppressor kinase 2. | Si:dkey-266m15.5. | 0.704 |
lats2 | mtus1a | ENSDARP00000114142 | ENSDARP00000096667 | Large tumor suppressor kinase 2. | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | 0.603 |
lats2 | sav1 | ENSDARP00000114142 | ENSDARP00000025090 | Large tumor suppressor kinase 2. | Salvador family WW domain-containing protein 1. | 0.964 |
mtus1a | LOC799520 | ENSDARP00000096667 | ENSDARP00000113517 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | Si:dkey-266m15.5. | 0.603 |
mtus1a | buc | ENSDARP00000096667 | ENSDARP00000125536 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | Bucky ball; Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis. Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains. Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body. Interaction of BUC protein and mRNA with rbpms2 and d [...] | 0.743 |
mtus1a | lats1 | ENSDARP00000096667 | ENSDARP00000027561 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | LATS, large tumor suppressor, homolog 1 (Drosophila). | 0.603 |
mtus1a | lats2 | ENSDARP00000096667 | ENSDARP00000114142 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | Large tumor suppressor kinase 2. | 0.603 |
mtus1a | mylipa | ENSDARP00000096667 | ENSDARP00000012386 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | E3 ubiquitin-protein ligase MYLIP-A; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway. | 0.796 |
mtus1a | sav1 | ENSDARP00000096667 | ENSDARP00000025090 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | Salvador family WW domain-containing protein 1. | 0.860 |
mtus1a | setdb1a | ENSDARP00000096667 | ENSDARP00000082769 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | Histone-lysine N-methyltransferase SETDB1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-re [...] | 0.999 |
mtus1a | tdrd1 | ENSDARP00000096667 | ENSDARP00000127267 | Microtubule-associated tumor suppressor 1 homolog A; May inhibit cell proliferation. | Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of corr [...] | 0.670 |