STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tnfrsf21Tumor necrosis factor receptor superfamily, member 21. (637 aa)    
Predicted Functional Partners:
appb
Amyloid beta (A4) precursor protein b.
   
 
 0.869
appa
Amyloid beta (A4) precursor protein a.
   
 
 0.869
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
    
 
 0.832
aplp2
Amyloid beta (A4) precursor-like protein 2.
   
 
 0.729
casp6a
Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.
      
 0.718
casp6b.1
Caspase 6b.1, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
      
 0.717
tnfrsf19
Tumor necrosis factor receptor superfamily, member 19.
      
 0.669
aplp1
Amyloid beta (A4) precursor-like protein 1.
   
 
 0.628
cfap45
Cilia and flagella-associated protein 45.
   
  
 0.600
dr1
Down-regulator of transcription 1.
      
 0.594
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.