STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
aplnrbApelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] (359 aa)    
Predicted Functional Partners:
apln
Apelin; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity).
   
 
 0.999
apela
Apelin receptor early endogenous ligand; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast m [...]
    
 
 0.993
aplnr2
Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family.
  
  
0.905
aplnra
Apelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...]
  
  
0.903
gnai3
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 3.
    
 0.864
gnb1b
Guanine nucleotide binding protein (G protein), beta polypeptide 1, like.
   
  0.811
gnb1a
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).
   
  0.810
GNB4
G protein subunit beta 4.
    
  0.809
gnb2
Guanine nucleotide-binding protein (G protein), beta polypeptide 2.
    
  0.809
gnb4b
Guanine nucleotide-binding protein (G protein), beta polypeptide 4b.
    
  0.809
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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