STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dmrt1Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in sex determination and differentiation by controlling gonad development and germ cell proliferation. Acts both as a transcription repressor and activator (By similarity); Belongs to the DMRT family (268 aa)    
Predicted Functional Partners:
amh
Muellerian-inhibiting factor precursor; anti-Mullerian hormone
   
  
 0.972
foxl2
Forkhead box protein l2a; Forkhead box L2
    
 
 0.970
FOXL2
Forkhead box protein l2b; Uncharacterized protein; Forkhead box L2
    
 
 0.970
cyp19a1a
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens
    
 
 0.922
cyp11c1
Cytochrome P450, family 11, subfamily C, polypeptide 1
    
 
 0.824
nr0b1
Nuclear receptor subfamily 0, group B, member 1
   
 
 0.800
atf7ip
Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity)
      
 0.772
sox3
Transcription factor sox1/3/14/21 (sox group b); Transcription factor Sox-3; Transcriptional activator
   
 
 0.759
sox9a
Transcription factor sox9 (sox group e); SRY (sex determining region Y)-box 9a; SRY-box containing gene 9a
    
 
 0.749
cyp19a1b
Cytochrome p450 19a1b; Cytochrome P450, family 19, subfamily A, polypeptide 1b
    
 
 0.734
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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