STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mtmr10Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (765 aa)    
Predicted Functional Partners:
OTUD7A
Si:dkey-37f18.2.
      
 0.689
mtmr2
Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).
   
 
0.582
lrguk
Leucine-rich repeats and guanylate kinase domain-containing.
   
 
 0.509
klf13
Kruppel-like factor 13.
    
 
 0.504
styxl1
Serine/threonine/tyrosine-interacting-like 1.
    
 
 0.501
mtmr11
Myotubularin-related protein 11.
      
0.487
fan1
Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'- flap annealing until i [...]
      
 0.471
mtmr12
Myotubularin-related protein 12; Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location. By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis. In skeletal muscle cells, does not regulate mtm1 subcellular localization.
   
  
0.470
trpm1a
Transient receptor potential cation channel, subfamily M, member 1a.
 
    
 0.463
FIG4
FIG4 phosphoinositide 5-phosphatase.
   
  
 0.411
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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