node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alkbh5 | fto | ENSDARP00000086116 | ENSDARP00000107656 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | FTO alpha-ketoglutarate-dependent dioxygenase. | 0.998 |
alkbh5 | hnrnpc | ENSDARP00000086116 | ENSDARP00000070385 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | Heterogeneous nuclear ribonucleoprotein C. | 0.855 |
alkbh5 | mettl14 | ENSDARP00000086116 | ENSDARP00000093767 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. | 0.999 |
alkbh5 | rbm15 | ENSDARP00000086116 | ENSDARP00000100758 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | RNA-binding motif protein 15. | 0.943 |
alkbh5 | rbmx | ENSDARP00000086116 | ENSDARP00000111610 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | RNA-binding motif protein, X chromosome; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity). Required for embryonic development, in particular of the brain. | 0.744 |
alkbh5 | virma | ENSDARP00000086116 | ENSDARP00000131427 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | Vir-like m6A methyltransferase-associated. | 0.882 |
alkbh5 | wtap | ENSDARP00000086116 | ENSDARP00000062551 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | Pre-mRNA-splicing regulator WTAP; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. | 0.996 |
alkbh5 | ythdf3 | ENSDARP00000086116 | ENSDARP00000109970 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | YTH N(6)-methyladenosine RNA-binding protein 3. | 0.946 |
alkbh5 | zc3h13 | ENSDARP00000086116 | ENSDARP00000054063 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | Zinc finger CCCH-type-containing 13. | 0.912 |
eif4g2b | mettl14 | ENSDARP00000074210 | ENSDARP00000093767 | Eukaryotic translation initiation factor 4, gamma 2b. | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. | 0.512 |
eif4g2b | ythdf3 | ENSDARP00000074210 | ENSDARP00000109970 | Eukaryotic translation initiation factor 4, gamma 2b. | YTH N(6)-methyladenosine RNA-binding protein 3. | 0.989 |
fto | alkbh5 | ENSDARP00000107656 | ENSDARP00000086116 | FTO alpha-ketoglutarate-dependent dioxygenase. | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron. | 0.998 |
fto | hnrnpc | ENSDARP00000107656 | ENSDARP00000070385 | FTO alpha-ketoglutarate-dependent dioxygenase. | Heterogeneous nuclear ribonucleoprotein C. | 0.772 |
fto | mettl14 | ENSDARP00000107656 | ENSDARP00000093767 | FTO alpha-ketoglutarate-dependent dioxygenase. | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. | 0.967 |
fto | rbm15 | ENSDARP00000107656 | ENSDARP00000100758 | FTO alpha-ketoglutarate-dependent dioxygenase. | RNA-binding motif protein 15. | 0.845 |
fto | rbmx | ENSDARP00000107656 | ENSDARP00000111610 | FTO alpha-ketoglutarate-dependent dioxygenase. | RNA-binding motif protein, X chromosome; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity). Required for embryonic development, in particular of the brain. | 0.495 |
fto | virma | ENSDARP00000107656 | ENSDARP00000131427 | FTO alpha-ketoglutarate-dependent dioxygenase. | Vir-like m6A methyltransferase-associated. | 0.812 |
fto | wtap | ENSDARP00000107656 | ENSDARP00000062551 | FTO alpha-ketoglutarate-dependent dioxygenase. | Pre-mRNA-splicing regulator WTAP; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. | 0.956 |
fto | ythdf3 | ENSDARP00000107656 | ENSDARP00000109970 | FTO alpha-ketoglutarate-dependent dioxygenase. | YTH N(6)-methyladenosine RNA-binding protein 3. | 0.869 |
fto | zc3h13 | ENSDARP00000107656 | ENSDARP00000054063 | FTO alpha-ketoglutarate-dependent dioxygenase. | Zinc finger CCCH-type-containing 13. | 0.845 |