STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ifit11Interferon-induced protein with tetratricopeptide repeats 11. (483 aa)    
Predicted Functional Partners:
leo1
RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development.
    
 
 0.639
rsad2
Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon; Belongs to the radical SAM superfamily. RSAD2 family.
   
 
 0.595
comtd1
Catechol-O-methyltransferase domain-containing 1.
  
 
 0.553
ND4
NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
   
 
 0.549
ifih1
Interferon-induced with helicase C domain 1.
   
 
 0.539
usp18
Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family.
   
 
 0.533
pkz
Protein kinase-containing Z-DNA-binding domains.
   
 
 0.496
wdr90
WD repeat domain 90.
    
 
 0.483
slc16a12b
Monocarboxylate transporter 12-B; Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
      
 0.453
eif2ak2
Eukaryotic translation initiation factor 2-alpha kinase 2.
   
 
 0.449
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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