STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sp9Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos; Belongs to the Sp1 C2H2-type zinc-finger protein family (447 aa)    
Predicted Functional Partners:
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
    
 
 0.688
ferd3l
Fer3-like bHLH transcription factor; Fer3-like (Drosophila)
    
 
 0.591
gsx1
Genetic screen homeobox 1 protein; GS homeobox 1
   
 0.545
nptnb
Neuroplastin b precursor; Neuroplastin b
   
  
 0.507
gstz1
Maleylacetoacetate isomerase isoform 2; Belongs to the GST superfamily
    
 
 0.479
olfcj1
Olfactory receptor cj1 precursor; Olfactory receptor C family, j1
      
 0.463
MMP28
Matrix metalloproteinase-28 (epilysin); Matrix metallopeptidase 28
      
 0.463
ola1
Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily
    
 
 0.450
fgf8a
Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis
    
 
 0.444
etv1
Ets variant gene 1
    
 0.443
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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