STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fbxl15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway (By similarity). Required for dorsal/ventral pattern formation. (310 aa)    
Predicted Functional Partners:
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
   
 0.991
cul1a
Cullin 1a; Belongs to the cullin family.
   
 0.943
cul1b
Cullin 1b; Belongs to the cullin family.
    
 
 0.885
fbxo33
F-box protein 33.
      
 0.855
fbxo11a
F-box protein 11a.
     
 0.809
zgc:175088
Zgc:175088 protein.
     
 0.789
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.783
fbxw10
F-box and WD repeat domain-containing 10.
    
 0.762
fbxo45
F-box/SPRY domain-containing protein 1; Belongs to the FBXO45/Fsn family.
   
  
 0.753
fbxw2
F-box and WD repeat domain-containing 2.
     
 0.742
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.