node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ip6k1 | ip6k2a | ENSDARP00000147201 | ENSDARP00000011601 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.914 |
ip6k1 | ip6k2b | ENSDARP00000147201 | ENSDARP00000024046 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.907 |
ip6k1 | ippk | ENSDARP00000147201 | ENSDARP00000113709 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation. InsP6 also acts as a key regulator of left- right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification. | 0.936 |
ip6k1 | ppip5k1a | ENSDARP00000147201 | ENSDARP00000097715 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ip6k1 | ppip5k1b | ENSDARP00000147201 | ENSDARP00000102480 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ip6k1 | ppip5k2 | ENSDARP00000147201 | ENSDARP00000115535 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.963 |
ip6k2a | ip6k1 | ENSDARP00000011601 | ENSDARP00000147201 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.914 |
ip6k2a | ip6k2b | ENSDARP00000011601 | ENSDARP00000024046 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.903 |
ip6k2a | ippk | ENSDARP00000011601 | ENSDARP00000113709 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation. InsP6 also acts as a key regulator of left- right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification. | 0.936 |
ip6k2a | itpk1a | ENSDARP00000011601 | ENSDARP00000009878 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. May also act as an isomerase that interconverts the inositol tetrakisphos [...] | 0.407 |
ip6k2a | ppip5k1a | ENSDARP00000011601 | ENSDARP00000097715 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ip6k2a | ppip5k1b | ENSDARP00000011601 | ENSDARP00000102480 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ip6k2a | ppip5k2 | ENSDARP00000011601 | ENSDARP00000115535 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ip6k2b | ip6k1 | ENSDARP00000024046 | ENSDARP00000147201 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.907 |
ip6k2b | ip6k2a | ENSDARP00000024046 | ENSDARP00000011601 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.903 |
ip6k2b | ippk | ENSDARP00000024046 | ENSDARP00000113709 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation. InsP6 also acts as a key regulator of left- right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification. | 0.936 |
ip6k2b | ppip5k1a | ENSDARP00000024046 | ENSDARP00000097715 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ip6k2b | ppip5k1b | ENSDARP00000024046 | ENSDARP00000102480 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ip6k2b | ppip5k2 | ENSDARP00000024046 | ENSDARP00000115535 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.938 |
ipmka | ipmkb | ENSDARP00000113169 | ENSDARP00000048865 | Kinase; Belongs to the inositol phosphokinase (IPK) family. | Kinase; Belongs to the inositol phosphokinase (IPK) family. | 0.904 |