STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
paxip1PAX-interacting protein 1; Involved in DNA damage response. May function as transcriptional cofactor in TGF beta signaling. Accentuates Smad2- dependent transcription (By similarity). (1122 aa)    
Predicted Functional Partners:
tp53bp1
Tumor protein p53-binding protein, 1.
    
 
 0.908
slf1
SMC5-SMC6 complex localization factor 1.
   
 
 0.902
topbp1
DNA topoisomerase II-binding protein 1.
   
 
0.869
kdm6al
Ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1.
   
 0.864
kdm6a
Lysine (K)-specific demethylase 6A.
    
 0.863
kdm6bb
Lysine (K)-specific demethylase 6B, b.
    
 0.857
kdm6ba
Lysine (K)-specific demethylase 6B, a.
    
 0.857
atm
Non-specific serine/threonine protein kinase.
   
 
 0.852
pagr1
PAXIP1-associated glutamate-rich protein 1.
    
 0.844
rad51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 
 0.829
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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