node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
UBE2M | cul5a | ENSDARP00000138225 | ENSDARP00000100474 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | Cullin 5a; Belongs to the cullin family. | 0.729 |
UBE2M | dcun1d3 | ENSDARP00000138225 | ENSDARP00000114663 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | DCN1-like protein. | 0.850 |
UBE2M | nedd8 | ENSDARP00000138225 | ENSDARP00000021095 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | NEDD8 ubiquitin-like modifier. | 0.972 |
UBE2M | rbx1 | ENSDARP00000138225 | ENSDARP00000055431 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | Ring-box 1, E3 ubiquitin protein ligase. | 0.981 |
UBE2M | ube2f | ENSDARP00000138225 | ENSDARP00000094476 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.455 |
cfap298 | dcun1d3 | ENSDARP00000104844 | ENSDARP00000114663 | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. | DCN1-like protein. | 0.742 |
cfap298 | hddc2 | ENSDARP00000104844 | ENSDARP00000050728 | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. | HD domain-containing protein 2; Belongs to the HDDC2 family. | 0.664 |
cfap298 | mvb12a | ENSDARP00000104844 | ENSDARP00000137110 | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). | 0.645 |
cfap298 | tmem30b | ENSDARP00000104844 | ENSDARP00000070742 | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. | Cell cycle control protein; Belongs to the CDC50/LEM3 family. | 0.550 |
cul5a | UBE2M | ENSDARP00000100474 | ENSDARP00000138225 | Cullin 5a; Belongs to the cullin family. | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | 0.729 |
cul5a | dcun1d3 | ENSDARP00000100474 | ENSDARP00000114663 | Cullin 5a; Belongs to the cullin family. | DCN1-like protein. | 0.725 |
cul5a | nedd8 | ENSDARP00000100474 | ENSDARP00000021095 | Cullin 5a; Belongs to the cullin family. | NEDD8 ubiquitin-like modifier. | 0.966 |
cul5a | rbx1 | ENSDARP00000100474 | ENSDARP00000055431 | Cullin 5a; Belongs to the cullin family. | Ring-box 1, E3 ubiquitin protein ligase. | 0.997 |
cul5a | ube2f | ENSDARP00000100474 | ENSDARP00000094476 | Cullin 5a; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.851 |
dcun1d3 | UBE2M | ENSDARP00000114663 | ENSDARP00000138225 | DCN1-like protein. | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | 0.850 |
dcun1d3 | cfap298 | ENSDARP00000114663 | ENSDARP00000104844 | DCN1-like protein. | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. | 0.742 |
dcun1d3 | cul5a | ENSDARP00000114663 | ENSDARP00000100474 | DCN1-like protein. | Cullin 5a; Belongs to the cullin family. | 0.725 |
dcun1d3 | gpr173 | ENSDARP00000114663 | ENSDARP00000063004 | DCN1-like protein. | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (By similarity). | 0.806 |
dcun1d3 | hddc2 | ENSDARP00000114663 | ENSDARP00000050728 | DCN1-like protein. | HD domain-containing protein 2; Belongs to the HDDC2 family. | 0.765 |
dcun1d3 | mvb12a | ENSDARP00000114663 | ENSDARP00000137110 | DCN1-like protein. | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). | 0.954 |