STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pvalb2Parvalbumin-2; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)    
Predicted Functional Partners:
tpma
Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family.
   
 
 0.752
tnnc2
Fast skeletal muscle troponin C.
   
  
 0.681
mybphb
Myosin-binding protein Hb.
   
 
 0.681
pvalb1
Parvalbumin isoform 1d; Belongs to the parvalbumin family.
   
  
0.622
matn3a
Novel protein similar to vertebrate matrilin 3 (MATN3) (Zgc:101120).
   
 
 0.600
myl13
Atrial myosin light chain.
   
 
 0.581
casq1a
Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.
   
 
 0.577
ankrd29
Ankyrin repeat domain-containing protein 29.
    
 
 0.572
spsb3a
SplA/ryanodine receptor domain and SOCS box-containing 3a.
      
 0.568
spsb3b
SplA/ryanodine receptor domain and SOCS box-containing 3b.
      
 0.568
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.