STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdca7aCell division cycle-associated 7a. (408 aa)    
Predicted Functional Partners:
rfc2
Replication factor C (activator 1) 2.
   
 
 0.911
rfc4
Replication factor C (activator 1) 4.
   
 
 0.908
rad17
RAD17 checkpoint clamp loader component.
   
 
 0.890
rad1
RAD1 homolog (S. pombe).
    
 
 0.882
HUS1B
Checkpoint protein; Belongs to the HUS1 family.
   
 
 0.882
rfc3
Replication factor C (Activator 1) 3.
   
 
 0.822
slf1
SMC5-SMC6 complex localization factor 1.
    
 
 0.817
rfc5
Replication factor C (activator 1) 5.
   
 
 0.800
topbp1
DNA topoisomerase II-binding protein 1.
   
 
 0.737
rpa1
Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 
 0.722
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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