STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pi15aPeptidase inhibitor 15-A; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. (260 aa)    
Predicted Functional Partners:
gart
Phosphoribosylglycinamide formyltransferase.
    
  0.869
LOC568792
ADAM metallopeptidase with thrombospondin type 1 motif, 16.
      
 0.646
gpc2
Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
      
 0.638
creb3l2
Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...]
      
 0.599
adgrb3
Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family.
      
 0.564
nid1a
Nidogen 1a.
   
  
 0.552
creb3l1
cAMP-responsive element-binding protein 3-like 1.
      
 0.526
cubn
Cubilin (intrinsic factor-cobalamin receptor).
      
 0.512
enpep
Aminopeptidase.
      
 0.501
epha3
Ephrin type-A receptor 3.
   
  
 0.491
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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