STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shank2bSH3 and multiple ankyrin repeat domains 2b. (1800 aa)    
Predicted Functional Partners:
dlg4
Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity.
   
 0.829
nlgn1
Neuroligin 1.
   
 0.821
nrxn1a
Neurexin-1a-beta; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in formation or maintenance of synaptic junctions; Belongs to the neurexin family.
     
 0.749
NRXN2
Neurexin 2.
     
 0.740
dlg2
Disks large homolog 2; May play a role in synapse assembly and function.
   
 0.725
dlgap3
Discs, large (Drosophila) homolog-associated protein 3.
   
 0.718
dlg3
Discs, large homolog 3 (Drosophila); Belongs to the MAGUK family.
   
 0.710
dlgap1a
Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells. Belongs to the SAPAP family.
    
 0.697
dlgap4b
Discs, large (Drosophila) homolog-associated protein 4b.
    
 0.672
dpydb
Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity); Belongs to the dihydropyrimidine dehydrogenase family.
      
 0.670
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (78%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.