STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
loxl2bLysyl oxidase homolog 2B; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and probably specifically mediates deamination of histone H3. Involved in ep [...] (762 aa)    
Predicted Functional Partners:
fbln5
Fibulin-5 precursor; Fibulin 5
   
 0.947
loxl3b
Lysyl oxidase homolog 3B; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (By similarity). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (By similarity). Can mediate oxidation of lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues (By similarity). Required for maturation of neural crest derived car [...]
   
0.932
loxl4
Lysyl oxidase-like protein 2/3/4; Lysyl oxidase-like 4
   
0.931
lox
Protein-lysine 6-oxidase precursor; Lysyl oxidase
   
0.925
loxl1
Lysyl oxidase homolog 1 precursor; Lysyl oxidase-like 1
   
 
0.919
ltbp3
Latent-transforming growth factor beta-binding protein 3 precursor; Latent transforming growth factor beta binding protein 3
    
 0.916
tll1
Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes
     
 0.916
si:dkey-234i14.3
Si:dkey-234i14.3
    
  0.901
si:dkey-163f14.6
Uncharacterized protein si:dkey-163f14.6 isoform x2; Si:dkey-163f14.6
    
  0.901
zgc:66455
Uncharacterized protein loc393502 precursor; Zgc:66455
     
  0.900
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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