node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ND2 | ndufaf1 | ENSDARP00000087870 | ENSDARP00000118047 | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). | NADH:ubiquinone oxidoreductase complex assembly factor 1. | 0.988 |
ND2 | taz | ENSDARP00000087870 | ENSDARP00000120241 | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). | Tafazzin family protein; Belongs to the taffazin family. | 0.807 |
cds2 | crls1 | ENSDARP00000003167 | ENSDARP00000055384 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | Cardiolipin synthase 1. | 0.988 |
cds2 | lclat1 | ENSDARP00000003167 | ENSDARP00000138738 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | Lysocardiolipin acyltransferase 1; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol- 3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn- glycerol-3- phosphate (phosphatidic acid [...] | 0.938 |
cds2 | lpcat4 | ENSDARP00000003167 | ENSDARP00000050686 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | Lysophosphatidylcholine acyltransferase 4. | 0.435 |
cds2 | pgs1 | ENSDARP00000003167 | ENSDARP00000099089 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.991 |
cds2 | tamm41 | ENSDARP00000003167 | ENSDARP00000140867 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. | 0.838 |
cds2 | taz | ENSDARP00000003167 | ENSDARP00000120241 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | Tafazzin family protein; Belongs to the taffazin family. | 0.644 |
crls1 | cds2 | ENSDARP00000055384 | ENSDARP00000003167 | Cardiolipin synthase 1. | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | 0.988 |
crls1 | ephx2 | ENSDARP00000055384 | ENSDARP00000058889 | Cardiolipin synthase 1. | Epoxide hydrolase 2, cytoplasmic. | 0.555 |
crls1 | lclat1 | ENSDARP00000055384 | ENSDARP00000138738 | Cardiolipin synthase 1. | Lysocardiolipin acyltransferase 1; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol- 3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn- glycerol-3- phosphate (phosphatidic acid [...] | 0.928 |
crls1 | lpcat4 | ENSDARP00000055384 | ENSDARP00000050686 | Cardiolipin synthase 1. | Lysophosphatidylcholine acyltransferase 4. | 0.926 |
crls1 | pgs1 | ENSDARP00000055384 | ENSDARP00000099089 | Cardiolipin synthase 1. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.973 |
crls1 | ptpmt1 | ENSDARP00000055384 | ENSDARP00000068947 | Cardiolipin synthase 1. | Protein tyrosine phosphatase, mitochondrial 1. | 0.588 |
crls1 | tamm41 | ENSDARP00000055384 | ENSDARP00000140867 | Cardiolipin synthase 1. | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. | 0.704 |
crls1 | taz | ENSDARP00000055384 | ENSDARP00000120241 | Cardiolipin synthase 1. | Tafazzin family protein; Belongs to the taffazin family. | 0.968 |
ephx2 | crls1 | ENSDARP00000058889 | ENSDARP00000055384 | Epoxide hydrolase 2, cytoplasmic. | Cardiolipin synthase 1. | 0.555 |
ephx2 | pgs1 | ENSDARP00000058889 | ENSDARP00000099089 | Epoxide hydrolase 2, cytoplasmic. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.406 |
ephx2 | taz | ENSDARP00000058889 | ENSDARP00000120241 | Epoxide hydrolase 2, cytoplasmic. | Tafazzin family protein; Belongs to the taffazin family. | 0.606 |
lclat1 | cds2 | ENSDARP00000138738 | ENSDARP00000003167 | Lysocardiolipin acyltransferase 1; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol- 3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn- glycerol-3- phosphate (phosphatidic acid [...] | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | 0.938 |