STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nf2aSimilar to neurofibromin 2. (593 aa)    
Predicted Functional Partners:
amot
Angiomotin.
    
 0.957
amotl1
Angiomotin_C domain-containing protein.
    
 0.951
amotl2a
Angiomotin-like 2a; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments and for cell movements during embryogenesis. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family.
   
 0.939
amotl2b
Angiomotin-like 2b.
    
 0.938
nf2b
Neurofibromin 2b (merlin).
  
 
0.902
pak1
Non-specific serine/threonine protein kinase.
   
 0.783
hgs
Hepatocyte growth factor-regulated tyrosine kinase substrate.
    
 
 0.708
ENSDARP00000149604
Uncharacterized protein.
    
 
 0.659
lats1
LATS, large tumor suppressor, homolog 1 (Drosophila).
    
 
 0.655
lats2
Large tumor suppressor kinase 2.
    
 
 0.655
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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