STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mical1[F-actin]-monooxygenase mical1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and prevent repolymerization; Belongs to the Mical family. (1227 aa)    
Predicted Functional Partners:
rab35b
RAB35, member RAS oncogene family b.
      
 0.790
LOC100334911
Ankyrin repeat and sterile alpha motif domain-containing 1Aa.
   
 
 0.759
rab11fip5a
RAB11 family-interacting protein 5a (class I).
      
 0.646
pkn3
Protein kinase N3.
      
 0.587
brk1
Probable protein BRICK1; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity); Belongs to the BRK1 family.
      
 0.567
scamp2
Secretory carrier-associated membrane protein.
   
  
 0.565
rab8a
RAB8A, member RAS oncogene family.
   
 
 0.510
nphs1
NPHS1 adhesion molecule, nephrin.
   
  
 0.441
nckap1
Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity).
      
 0.438
plxnb2b
Plexin b2b.
    
 
 0.434
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.