STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hoxb1bHomeobox protein Hox-B1b; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments; Belongs to the Antp homeobox family. Labial subfamily. (229 aa)    
Predicted Functional Partners:
pbx4
Pre-B-cell leukemia transcription factor 4.
   
 
 0.944
pbx2
Pre-B-cell leukemia homeobox 2.
   
 
 0.908
meis3
Myeloid ecotropic viral integration site 3.
   
 
 0.852
egr2b
Early growth response protein 2b; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
    
 
 0.747
egr2a
Early growth response 2a.
    
 
 0.745
ppp1r14ab
Protein phosphatase 1, regulatory (inhibitor) subunit 14Ab.
   
  
 0.706
meis1b
Myeloid ecotropic viral integration 1.
   
 
 0.698
pknox1.1
Homeodomain transcription factor Prep1.
   
 
 0.678
hnf1ba
Hepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain.
   
  
 0.647
pbx1a
Pre-B-cell leukemia transcription factor 1a.
    
 
 0.646
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: high (84%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.