STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tfap2cTranscription factor AP-2 gamma (activating enhancer-binding protein 2 gamma). (445 aa)    
Predicted Functional Partners:
wwox
WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 0.919
cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2.
    
 0.730
prdm14
PR domain-containing 14.
    
 
 0.703
prdm1a
PR domain-containing 1a, with ZNF domain.
      
 0.657
kctd1
Potassium channel tetramerization domain-containing 1.
   
 0.642
foxd3
Forkhead box D3.
   
  
 0.627
gata3
Transcription factor GATA-3.
   
 
 0.604
myca
Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
    
 0.584
cited1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1.
    
 0.584
nanos3
Nanos homolog 3; Belongs to the nanos family.
   
  
 0.583
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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