STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mllt10MLLT10 histone lysine methyltransferase DOT1L cofactor. (1133 aa)    
Predicted Functional Partners:
dot1l
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
   
 
 0.953
mllt1a
MLLT1 super elongation complex subunit a.
   
 
 0.900
trip12
E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...]
      
 0.699
thnsl2
Threonine synthase-like 2; Acts as a catabolic phospho-lyase on both gamma- and beta- phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). Belongs to the threonine synthase family.
      
 0.692
mllt3
MLLT3 super elongation complex subunit.
    
 
 0.688
bcl7a
B-cell CLL/lymphoma 7 protein family member A.
      
 0.662
yeats4
YEATS domain-containing 4.
    
 
 0.649
ell
Elongation factor RNA polymerase II.
      
 0.615
afdna
Afadin, adherens junction formation factor a.
      
 0.595
prpf4bb
Pre-mRNA-processing factor 4Bb.
      
 0.587
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.