node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ada | dtymk | ENSDARP00000005284 | ENSDARP00000068373 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Deoxythymidylate kinase (thymidylate kinase). | 0.467 |
ada | itpa | ENSDARP00000005284 | ENSDARP00000074674 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.607 |
ada | nt5c2a | ENSDARP00000005284 | ENSDARP00000057573 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 5'-nucleotidase, cytosolic IIa. | 0.920 |
ada | nt5c2l1 | ENSDARP00000005284 | ENSDARP00000020283 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 5'-nucleotidase, cytosolic II,-like 1. | 0.920 |
ada | nt5c3a | ENSDARP00000005284 | ENSDARP00000124641 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Cytosolic 5'-nucleotidase 3; Can act both as nucleotidase and as phosphotransferase. | 0.911 |
ada | nt5e | ENSDARP00000005284 | ENSDARP00000095510 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 5'-nucleotidase, ecto (CD73); Belongs to the 5'-nucleotidase family. | 0.962 |
ada | tyms | ENSDARP00000005284 | ENSDARP00000047068 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Thymidylate synthetase. | 0.439 |
ada | umps | ENSDARP00000005284 | ENSDARP00000035728 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Uridine monophosphate synthetase. | 0.426 |
dtymk | ada | ENSDARP00000068373 | ENSDARP00000005284 | Deoxythymidylate kinase (thymidylate kinase). | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.467 |
dtymk | dut | ENSDARP00000068373 | ENSDARP00000156654 | Deoxythymidylate kinase (thymidylate kinase). | Deoxyuridine triphosphatase. | 0.984 |
dtymk | itpa | ENSDARP00000068373 | ENSDARP00000074674 | Deoxythymidylate kinase (thymidylate kinase). | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.593 |
dtymk | nt5c2a | ENSDARP00000068373 | ENSDARP00000057573 | Deoxythymidylate kinase (thymidylate kinase). | 5'-nucleotidase, cytosolic IIa. | 0.903 |
dtymk | nt5c2l1 | ENSDARP00000068373 | ENSDARP00000020283 | Deoxythymidylate kinase (thymidylate kinase). | 5'-nucleotidase, cytosolic II,-like 1. | 0.903 |
dtymk | nt5c3a | ENSDARP00000068373 | ENSDARP00000124641 | Deoxythymidylate kinase (thymidylate kinase). | Cytosolic 5'-nucleotidase 3; Can act both as nucleotidase and as phosphotransferase. | 0.913 |
dtymk | nt5e | ENSDARP00000068373 | ENSDARP00000095510 | Deoxythymidylate kinase (thymidylate kinase). | 5'-nucleotidase, ecto (CD73); Belongs to the 5'-nucleotidase family. | 0.919 |
dtymk | tyms | ENSDARP00000068373 | ENSDARP00000047068 | Deoxythymidylate kinase (thymidylate kinase). | Thymidylate synthetase. | 0.997 |
dtymk | umps | ENSDARP00000068373 | ENSDARP00000035728 | Deoxythymidylate kinase (thymidylate kinase). | Uridine monophosphate synthetase. | 0.868 |
dut | dtymk | ENSDARP00000156654 | ENSDARP00000068373 | Deoxyuridine triphosphatase. | Deoxythymidylate kinase (thymidylate kinase). | 0.984 |
dut | itpa | ENSDARP00000156654 | ENSDARP00000074674 | Deoxyuridine triphosphatase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.947 |
dut | nt5c2a | ENSDARP00000156654 | ENSDARP00000057573 | Deoxyuridine triphosphatase. | 5'-nucleotidase, cytosolic IIa. | 0.900 |