STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mcl1bMCL1 apoptosis regulator, BCL2 family member b. (228 aa)    
Predicted Functional Partners:
bcl2l11
BCL2-like 11.
    
 
 0.948
huwe1
HECT, UBA and WWE domain-containing E3 ubiquitin protein ligase 1.
    
 
 0.873
zgc:153993
Zgc:153993 protein.
    
 
 0.849
nitr2b
Novel immune-type receptor 2b, allele 1.
   
 
 0.754
boka
Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family.
    
 
 0.744
nitr4a
Novel immune-type receptor 4a.
      
 0.697
becn1
Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...]
    
 
 0.694
bokb
Bcl-2-related ovarian killer protein homolog B; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family.
    
 
 0.693
fosaa
V-fos FBJ murine osteosarcoma viral oncogene homolog Aa.
   
  
 0.677
apaf1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).
    
 
 0.676
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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