node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apaf1 | bcl2l11 | ENSDARP00000008347 | ENSDARP00000097551 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). | BCL2-like 11. | 0.781 |
apaf1 | boka | ENSDARP00000008347 | ENSDARP00000123964 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). | Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | 0.705 |
apaf1 | bokb | ENSDARP00000008347 | ENSDARP00000123352 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). | Bcl-2-related ovarian killer protein homolog B; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | 0.684 |
apaf1 | mcl1b | ENSDARP00000008347 | ENSDARP00000124404 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). | MCL1 apoptosis regulator, BCL2 family member b. | 0.676 |
apaf1 | zgc:153993 | ENSDARP00000008347 | ENSDARP00000139602 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). | Zgc:153993 protein. | 0.639 |
bcl2l11 | apaf1 | ENSDARP00000097551 | ENSDARP00000008347 | BCL2-like 11. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). | 0.781 |
bcl2l11 | becn1 | ENSDARP00000097551 | ENSDARP00000100986 | BCL2-like 11. | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | 0.745 |
bcl2l11 | boka | ENSDARP00000097551 | ENSDARP00000123964 | BCL2-like 11. | Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | 0.793 |
bcl2l11 | bokb | ENSDARP00000097551 | ENSDARP00000123352 | BCL2-like 11. | Bcl-2-related ovarian killer protein homolog B; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | 0.787 |
bcl2l11 | mcl1b | ENSDARP00000097551 | ENSDARP00000124404 | BCL2-like 11. | MCL1 apoptosis regulator, BCL2 family member b. | 0.948 |
bcl2l11 | zgc:153993 | ENSDARP00000097551 | ENSDARP00000139602 | BCL2-like 11. | Zgc:153993 protein. | 0.990 |
becn1 | bcl2l11 | ENSDARP00000100986 | ENSDARP00000097551 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | BCL2-like 11. | 0.745 |
becn1 | boka | ENSDARP00000100986 | ENSDARP00000123964 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | 0.612 |
becn1 | bokb | ENSDARP00000100986 | ENSDARP00000123352 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Bcl-2-related ovarian killer protein homolog B; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | 0.669 |
becn1 | mcl1b | ENSDARP00000100986 | ENSDARP00000124404 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | MCL1 apoptosis regulator, BCL2 family member b. | 0.694 |
becn1 | zgc:153993 | ENSDARP00000100986 | ENSDARP00000139602 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | Zgc:153993 protein. | 0.605 |
boka | apaf1 | ENSDARP00000123964 | ENSDARP00000008347 | Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). | 0.705 |
boka | bcl2l11 | ENSDARP00000123964 | ENSDARP00000097551 | Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | BCL2-like 11. | 0.793 |
boka | becn1 | ENSDARP00000123964 | ENSDARP00000100986 | Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | 0.612 |
boka | mcl1b | ENSDARP00000123964 | ENSDARP00000124404 | Bcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. | MCL1 apoptosis regulator, BCL2 family member b. | 0.744 |