STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
map3k14aMitogen-activated protein kinase kinase kinase 14a. (825 aa)    
Predicted Functional Partners:
ikbkb
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
0.963
chuk
Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
   
0.956
traf3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.956
traf2a
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.943
traf2b
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.943
ikbkg
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.923
map3k7
Mitogen-activated protein kinase kinase kinase 7.
    
0.915
map3k8
Mitogen-activated protein kinase kinase kinase 8.
    
0.912
LOC795766
ADP-ribosylation factor 2b.
  
  
 
0.908
tnfrsf11a
Tumor necrosis factor receptor superfamily, member 11a, NFKB activator.
     
 0.826
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (38%) [HD]