STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrbThyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. (508 aa)    
Predicted Functional Partners:
dio2
Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).
   
  
 0.905
dio1
Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).
   
  
 0.862
slc16a10
Monocarboxylate transporter 10; Sodium-independent transporter that mediates the uptake of aromatic acids; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
    
 
 0.832
ugt1a1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
      
 0.831
slco1c1
Solute carrier organic anion transporter family member.
      
 0.831
ttr
Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
      
 0.808
tg
Thyroglobulin.
      
 0.807
ncor2
Nuclear receptor corepressor 2.
   
 0.795
tshba
Thyroid-stimulating hormone subunit beta a.
   
  
 0.756
ncor1
Nuclear receptor corepressor 1.
    
 
 0.730
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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