STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
scn8abSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1958 aa)    
Predicted Functional Partners:
scn4ba
Voltage-gated sodium channel beta 4 subunit locus 1.
   
 0.916
casp8ap2
Caspase 8-associated protein 2.
      
 0.830
cacnb4a
Voltage-gated calcium channel beta-4 subunit variant 2.
   
 
 0.806
scn1bb
Sodium channel, voltage-gated, type I, beta b.
   
 0.780
scn1ba
Voltage-gated sodium channel beta 1 subunit splice variant D.
   
 0.779
scn2b
Voltage-gated sodium channel beta 2 subunit splice variant D.
   
 0.764
scn3b
Sodium channel, voltage-gated, type III, beta.
   
 0.700
ENSDARP00000156876
Ion_trans domain-containing protein.
  
0.694
cacna1hb
Calcium channel, voltage-dependent, T type, alpha 1H subunit b.
  
0.691
cacna1ib
Calcium voltage-gated channel subunit alpha1 Ib.
  
0.688
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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