node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
X1WHF1_DANRE | cenpa | ENSDARP00000129663 | ENSDARP00000153106 | Histone H2B; Belongs to the histone H2B family. | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | 0.842 |
X1WHF1_DANRE | hist1h2a3 | ENSDARP00000129663 | ENSDARP00000093780 | Histone H2B; Belongs to the histone H2B family. | Histone H2A; Belongs to the histone H2A family. | 0.999 |
X1WHF1_DANRE | hist2h2l | ENSDARP00000129663 | ENSDARP00000055912 | Histone H2B; Belongs to the histone H2B family. | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.405 |
X1WHF1_DANRE | plk1 | ENSDARP00000129663 | ENSDARP00000075786 | Histone H2B; Belongs to the histone H2B family. | Serine/threonine-protein kinase PLK. | 0.655 |
cdc20 | cenpa | ENSDARP00000140575 | ENSDARP00000153106 | Cell division cycle 20 homolog. | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | 0.887 |
cdc20 | cenpi | ENSDARP00000140575 | ENSDARP00000068927 | Cell division cycle 20 homolog. | Centromere protein I. | 0.814 |
cdc20 | cenpn | ENSDARP00000140575 | ENSDARP00000064079 | Cell division cycle 20 homolog. | Centromere protein N. | 0.776 |
cdc20 | cenps | ENSDARP00000140575 | ENSDARP00000094265 | Cell division cycle 20 homolog. | Similar to apoptosis-inducing, TAF9-like domain 1. | 0.632 |
cdc20 | cenpt | ENSDARP00000140575 | ENSDARP00000120776 | Cell division cycle 20 homolog. | Si:ch211-225g23.1. | 0.685 |
cdc20 | nudc | ENSDARP00000140575 | ENSDARP00000136053 | Cell division cycle 20 homolog. | NudC nuclear distribution protein. | 0.813 |
cdc20 | plk1 | ENSDARP00000140575 | ENSDARP00000075786 | Cell division cycle 20 homolog. | Serine/threonine-protein kinase PLK. | 0.993 |
cenpa | X1WHF1_DANRE | ENSDARP00000153106 | ENSDARP00000129663 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Histone H2B; Belongs to the histone H2B family. | 0.842 |
cenpa | cdc20 | ENSDARP00000153106 | ENSDARP00000140575 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Cell division cycle 20 homolog. | 0.887 |
cenpa | cenpi | ENSDARP00000153106 | ENSDARP00000068927 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Centromere protein I. | 0.864 |
cenpa | cenpn | ENSDARP00000153106 | ENSDARP00000064079 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Centromere protein N. | 0.870 |
cenpa | cenps | ENSDARP00000153106 | ENSDARP00000094265 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Similar to apoptosis-inducing, TAF9-like domain 1. | 0.862 |
cenpa | cenpt | ENSDARP00000153106 | ENSDARP00000120776 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Si:ch211-225g23.1. | 0.866 |
cenpa | hist1h2a3 | ENSDARP00000153106 | ENSDARP00000093780 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Histone H2A; Belongs to the histone H2A family. | 0.830 |
cenpa | hist2h2l | ENSDARP00000153106 | ENSDARP00000055912 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.846 |
cenpa | nudc | ENSDARP00000153106 | ENSDARP00000136053 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] | NudC nuclear distribution protein. | 0.808 |