STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnf144aaProbable E3 ubiquitin-protein ligase RNF144A-A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (293 aa)    
Predicted Functional Partners:
cmpk2
Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial.
      
 0.959
prkdc
Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.
    
 0.872
ywhaqa
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family.
      
 0.860
ube2l3b
Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.676
rps27a
Ribosomal protein S27a.
   
 0.668
rsad2
Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon; Belongs to the radical SAM superfamily. RSAD2 family.
 
    
 0.626
ubb
Ubiquitin B.
   
 0.596
UBB
Si:ch211-202a12.4.
    
 0.594
ubc
Ubiquitin C.
    
 0.594
ciao1
Probable cytosolic iron-sulfur protein assembly protein ciao1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.
      
 0.586
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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