node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC103911725 | uba3 | ENSDARP00000125076 | ENSDARP00000075198 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | 0.804 |
LOC103911725 | uba5 | ENSDARP00000125076 | ENSDARP00000087478 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2. | 0.804 |
UBE2M | uba3 | ENSDARP00000138225 | ENSDARP00000075198 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | 0.991 |
UBE2M | uba5 | ENSDARP00000138225 | ENSDARP00000087478 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2. | 0.832 |
UBE2M | ube2f | ENSDARP00000138225 | ENSDARP00000094476 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.455 |
UBE2M | ufc1 | ENSDARP00000138225 | ENSDARP00000036899 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage. | 0.505 |
UBE2M | ufm1 | ENSDARP00000138225 | ENSDARP00000064392 | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. Belongs to the UFM1 family. | 0.535 |
cdk5rap3 | uba5 | ENSDARP00000114762 | ENSDARP00000087478 | CDK5 regulatory subunit-associated protein 3. | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2. | 0.876 |
cdk5rap3 | ufc1 | ENSDARP00000114762 | ENSDARP00000036899 | CDK5 regulatory subunit-associated protein 3. | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage. | 0.875 |
cdk5rap3 | ufl1 | ENSDARP00000114762 | ENSDARP00000021768 | CDK5 regulatory subunit-associated protein 3. | E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. | 0.990 |
cdk5rap3 | ufm1 | ENSDARP00000114762 | ENSDARP00000064392 | CDK5 regulatory subunit-associated protein 3. | Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. Belongs to the UFM1 family. | 0.836 |
cdk5rap3 | ufsp1 | ENSDARP00000114762 | ENSDARP00000082474 | CDK5 regulatory subunit-associated protein 3. | UFM1-specific peptidase 1 (non-functional). | 0.486 |
cdk5rap3 | ufsp2 | ENSDARP00000114762 | ENSDARP00000110184 | CDK5 regulatory subunit-associated protein 3. | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins; Belongs to the peptidase C78 family. | 0.911 |
uba3 | LOC103911725 | ENSDARP00000075198 | ENSDARP00000125076 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | 0.804 |
uba3 | UBE2M | ENSDARP00000075198 | ENSDARP00000138225 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. | 0.991 |
uba3 | uba5 | ENSDARP00000075198 | ENSDARP00000087478 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2. | 0.804 |
uba3 | ube2f | ENSDARP00000075198 | ENSDARP00000094476 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.992 |
uba3 | ufc1 | ENSDARP00000075198 | ENSDARP00000036899 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage. | 0.654 |
uba3 | ufm1 | ENSDARP00000075198 | ENSDARP00000064392 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. Belongs to the UFM1 family. | 0.828 |
uba5 | LOC103911725 | ENSDARP00000087478 | ENSDARP00000125076 | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2. | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | 0.804 |