STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
espl1Extra spindle pole bodies-like 1, separase. (2182 aa)    
Predicted Functional Partners:
pttg1
PTTG1 regulator of sister chromatid separation, securin.
   
 0.999
smc3
Structural maintenance of chromosomes protein.
   
 0.995
rad21a
Double-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...]
   
 0.991
plk1
Serine/threonine-protein kinase PLK.
   
 0.989
LOC108192159
REC8 meiotic recombination protein a.
   
 0.988
smc1a
Structural maintenance of chromosomes protein.
   
 0.987
smc1al
Structural maintenance of chromosomes protein.
   
 0.987
smc1b
Structural maintenance of chromosomes protein.
   
 0.972
rad21l1
RAD21 cohesin complex component-like 1.
   
 0.969
rad21b
RAD21 cohesin complex component b.
   
 0.969
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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