STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nkl.1NK-lysin tandem duplicate 2. (149 aa)    
Predicted Functional Partners:
prf1.1
Perforin 1.1.
   
  
 0.814
fcer1gl
Fc receptor, IgE, high affinity I, gamma polypeptide-like.
   
  
 0.807
nitr2b
Novel immune-type receptor 2b, allele 1.
      
 0.805
gzmk
Granzyme K.
   
  
 0.805
nitr4a
Novel immune-type receptor 4a.
      
 0.801
themis
Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family.
      
 0.748
nitr7b
Novel immune-type receptor 7b, allele 2.
      
 0.742
il2rb
Interleukin 2 receptor, beta.
   
  
 0.740
cd8a
CD8 antigen, alpha polypeptide.
   
  
 0.683
prf1.2
Perforin 1.2.
   
  
 0.671
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.