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hisH protein (Halalkalicoccus jeotgali) - STRING interaction network
"hisH" - Imidazole glycerol phosphate synthase subunit HisH in Halalkalicoccus jeotgali
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (222 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (270 aa)
  0.999
hisA
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (242 aa)
 
  0.994
hisB
Imidazoleglycerol-phosphate dehydratase (195 aa)
 
 
  0.993
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (441 aa)
 
   
  0.986
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (282 aa)
 
   
  0.956
C497_08988
Bifunctional purine biosynthesis protein PurH (525 aa)
   
 
  0.949
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (122 aa)
 
   
  0.941
hisC
Histidinol-phosphate aminotransferase (359 aa)
 
   
  0.908
C497_07999
L-threonine-O-3-phosphate decarboxylase (336 aa)
 
   
  0.864
C497_08993
Adenylosuccinate lyase (464 aa)
   
 
    0.847
Your Current Organism:
Halalkalicoccus jeotgali
NCBI taxonomy Id: 795797
Other names: H. jeotgali, H. jeotgali B3, Halalkalicoccus, Halalkalicoccus Xue et al. 2005, Halalkalicoccus jeotgali, Halalkalicoccus jeotgali B3, Halalkalicoccus jeotgali DSM 18796, Halalkalicoccus jeotgali JCM 14584, Halalkalicoccus jeotgali Roh et al. 2007, Halalkalicoccus jeotgali str. B3, Halalkalicoccus jeotgali strain B3
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