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nfo protein (Halalkalicoccus jeotgali) - STRING interaction network
"nfo" - DNA-(apurinic or apyrimidinic site) lyase in Halalkalicoccus jeotgali
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nfoDNA-(apurinic or apyrimidinic site) lyase; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5’-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (276 aa)    
Predicted Functional Partners:
C497_07924
Type 11 methyltransferase (265 aa)
              0.875
C497_18542
Hef nuclease (799 aa)
     
 
  0.832
C497_07914
Hypothetical protein (49 aa)
              0.724
C497_08839
DNA-(apurinic or apyrimidinic site) lyase (267 aa)
   
 
  0.694
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (227 aa)
   
 
  0.694
topA
DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...] (853 aa)
   
 
  0.689
C497_08349
Pyruvate kinase (594 aa)
         
  0.641
C497_13623
HhH-GPD family protein (298 aa)
     
   
  0.616
HacjB3_12550
PHP domain-containing protein (580 aa)
         
  0.607
C497_07354
DNA-directed DNA polymerase type II (894 aa)
 
 
  0.576
Your Current Organism:
Halalkalicoccus jeotgali
NCBI taxonomy Id: 795797
Other names: H. jeotgali, H. jeotgali B3, Halalkalicoccus, Halalkalicoccus Xue et al. 2005, Halalkalicoccus jeotgali, Halalkalicoccus jeotgali B3, Halalkalicoccus jeotgali DSM 18796, Halalkalicoccus jeotgali JCM 14584, Halalkalicoccus jeotgali Roh et al. 2007, Halalkalicoccus jeotgali str. B3, Halalkalicoccus jeotgali strain B3
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