STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1Topoisomerase (DNA) II binding protein 1. (1450 aa)    
Predicted Functional Partners:
CSKR_12149s
53-BP1_Tudor domain-containing protein.
    
 
 0.989
CLF_106825
Uncharacterized protein.
    
 0.988
CDC45
Cell division control protein 45-like protein.
   
 
 0.987
Atr
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
    
 0.986
BRCA1
Breast cancer type 1 susceptibility-like protein.
   
 0.986
BRIP1
Fanconi anemia group J protein.
   
 0.985
mcm5
DNA helicase; Belongs to the MCM family.
   
 
 0.970
CTTNBP2
Cortactin-binding protein 2.
   
 0.959
Mcm3
DNA helicase; Belongs to the MCM family.
   
 
 0.959
BARD1
BRCA1-associated RING domain protein 1.
   
 0.959
Your Current Organism:
Clonorchis sinensis
NCBI taxonomy Id: 79923
Other names: C. sinensis, oriental liver fluke
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.