STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSFHEP00000015383Potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6. (372 aa)    
Predicted Functional Partners:
cftr
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
    
 0.653
LOC105921984
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.638
SGK1
Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
     
 0.638
sgk2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.638
LOC105932011
Uncharacterized protein.
  
 
 
0.634
LOC105926478
Potassium inwardly-rectifying channel, subfamily J, member 16.
  
 
 
0.622
KCNJ15
Potassium voltage-gated channel subfamily J member 15.
  
 
 
0.526
LOC105933732
ATP-sensitive inward rectifier potassium channel 10.
  
 
 
0.526
ENSFHEP00000003430
Uncharacterized protein.
   
 
 
0.504
bsnd
Uncharacterized protein.
   
  
 0.497
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.