STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC105917085Mitogen-activated protein kinase. (420 aa)    
Predicted Functional Partners:
map2k4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
   
0.997
LOC105927386
Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.
   
0.997
LOC105928914
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
    
 0.993
mapk10
Mitogen-activated protein kinase 10.
  
 
0.991
ENSFHEP00000013026
JunE proto-oncogene, AP-1 transcription factor subunit.
    
 0.991
LOC105938700
Mitogen-activated protein kinase.
  
 
0.990
LOC105930852
Mitogen-activated protein kinase.
  
 
0.988
nfatc3
Nuclear factor of activated T cells 3a.
    
 0.986
LOC105934647
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.983
map2k7
Mitogen-activated protein kinase kinase 7.
    
0.983
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.