STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLHL11BTB domain-containing protein. (710 aa)    
Predicted Functional Partners:
LOC101172920
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.937
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.937
cul1
Cullin 1b; Belongs to the cullin family.
    
 0.811
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
     
 0.641
commd4
COMM domain containing 4.
     
 0.620
H2MG95_ORYLA
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.591
kctd7
Potassium channel tetramerization domain containing 7.
     
 0.588
LOC101170460
IgLON family member 5.
      
 0.558
kbtbd8
Kelch repeat and BTB (POZ) domain containing 8.
    
 
0.557
ENSORLP00000027520
Ubiquitin-like domain-containing protein.
     
 0.556
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.