LOC101155173 protein (Oryzias latipes) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

LOC101155173

Sema domain-containing protein. (1089 aa)

Predicted Functional Partners:

nrp1

0.641

LOC101175393

0.612

met

0.612

mst1r

0.612

LOC101162124

0.598

LOC101169201

0.598

LOC101159664

0.598

H2MR98_ORYLA

0.598

LOC101165957

0.598

PLXNA2

0.440

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2MR98_ORYLA	LOC101155173	ENSORLP00000021277	ENSORLP00000008277	Plexin_cytopl domain-containing protein.	Sema domain-containing protein.	0.598
H2MR98_ORYLA	LOC101175393	ENSORLP00000021277	ENSORLP00000004366	Plexin_cytopl domain-containing protein.	Macrophage stimulating 1 receptor a.	0.510
H2MR98_ORYLA	met	ENSORLP00000021277	ENSORLP00000024532	Plexin_cytopl domain-containing protein.	MET proto-oncogene, receptor tyrosine kinase.	0.510
H2MR98_ORYLA	mst1r	ENSORLP00000021277	ENSORLP00000034975	Plexin_cytopl domain-containing protein.	Macrophage stimulating 1 receptor b.	0.510
H2MR98_ORYLA	nrp1	ENSORLP00000021277	ENSORLP00000042087	Plexin_cytopl domain-containing protein.	Neuropilin; Belongs to the neuropilin family.	0.638
LOC101155173	H2MR98_ORYLA	ENSORLP00000008277	ENSORLP00000021277	Sema domain-containing protein.	Plexin_cytopl domain-containing protein.	0.598
LOC101155173	LOC101159664	ENSORLP00000008277	ENSORLP00000012643	Sema domain-containing protein.	Plexin b1b.	0.598
LOC101155173	LOC101162124	ENSORLP00000008277	ENSORLP00000001602	Sema domain-containing protein.	Plexin b1a.	0.598
LOC101155173	LOC101165957	ENSORLP00000008277	ENSORLP00000026052	Sema domain-containing protein.	Plexin B3.	0.598
LOC101155173	LOC101169201	ENSORLP00000008277	ENSORLP00000003520	Sema domain-containing protein.	Plexin b2b.	0.598
LOC101155173	LOC101175393	ENSORLP00000008277	ENSORLP00000004366	Sema domain-containing protein.	Macrophage stimulating 1 receptor a.	0.612
LOC101155173	PLXNA2	ENSORLP00000008277	ENSORLP00000009631	Sema domain-containing protein.	Plexin A2.	0.440
LOC101155173	met	ENSORLP00000008277	ENSORLP00000024532	Sema domain-containing protein.	MET proto-oncogene, receptor tyrosine kinase.	0.612
LOC101155173	mst1r	ENSORLP00000008277	ENSORLP00000034975	Sema domain-containing protein.	Macrophage stimulating 1 receptor b.	0.612
LOC101155173	nrp1	ENSORLP00000008277	ENSORLP00000042087	Sema domain-containing protein.	Neuropilin; Belongs to the neuropilin family.	0.641
LOC101159664	LOC101155173	ENSORLP00000012643	ENSORLP00000008277	Plexin b1b.	Sema domain-containing protein.	0.598
LOC101159664	LOC101162124	ENSORLP00000012643	ENSORLP00000001602	Plexin b1b.	Plexin b1a.	0.548
LOC101159664	LOC101165957	ENSORLP00000012643	ENSORLP00000026052	Plexin b1b.	Plexin B3.	0.550
LOC101159664	LOC101169201	ENSORLP00000012643	ENSORLP00000003520	Plexin b1b.	Plexin b2b.	0.540
LOC101159664	LOC101175393	ENSORLP00000012643	ENSORLP00000004366	Plexin b1b.	Macrophage stimulating 1 receptor a.	0.510

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.859

expected number of edges:

13

PPI enrichment p-value:

5.81e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

5 of 111

1.96

2.45

6.23e-06

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1020

1.34

2.31

1.52e-11

GO:0007600

Sensory perception

4 of 347

1.37

0.8

0.0161

GO:0003008

System process

6 of 1127

1.03

0.74

0.0062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

5 of 26

2.59

4.36

4.38e-09

GO:0001664

G protein-coupled receptor binding

4 of 194

1.62

1.31

0.0013

GO:0048018

Receptor ligand activity

5 of 421

1.38

1.16

0.0013

GO:0005515

Protein binding

11 of 6815

0.52

0.41

0.0013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 50

2.31

3.68

4.27e-08

GO:0030141

Secretory granule

3 of 149

1.61

1.08

0.0051

GO:0030425

Dendrite

4 of 389

1.32

0.99

0.0035

GO:0043679

Axon terminus

2 of 50

1.91

0.85

0.0241

GO:0005886

Plasma membrane

8 of 5191

0.5

0.31

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21631

Mixed, incl. GTPase complex, and G protein-coupled amine receptor activity

7 of 147

1.99

3.86

9.47e-10

CL:22019

Galanin receptor activity, and Neuropeptide binding

4 of 15

2.73

3.83

7.03e-08

CL:21640

GTPase complex, and G protein-coupled amine receptor activity

6 of 115

2.03

3.51

1.53e-08

CL:21653

G beta:gamma signalling through BTK, and Amino terminal of the G-protein receptor rhodopsin

4 of 23

2.55

3.45

2.82e-07

CL:22023

Vertebrate endogenous opioids neuropeptide, and Neuropeptide binding

3 of 6

3.01

3.06

2.63e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

5 of 208

1.69

2.15

6.51e-06

map04080

Neuroactive ligand-receptor interaction

6 of 706

1.24

1.34

4.05e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-202040

G-protein activation

8 of 38

2.63

8.11

4.57e-17

MAP-111885

Opioid Signalling

8 of 114

2.15

5.71

4.18e-14

MAP-418594

G alpha (i) signalling events

11 of 430

1.72

4.43

1.28e-16

MAP-392451

G beta:gamma signalling through PI3Kgamma

5 of 39

2.42

4.36

2.21e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

5 of 46

2.34

4.16

4.25e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 15

2.73

3.61

1.85e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

5 of 64

2.2

3.59

3.79e-08

KW-0807

Transducer

6 of 629

1.29

1.42

3.61e-05

KW-1003

Cell membrane

5 of 464

1.34

1.33

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01160

Vertebrate endogenous opioids neuropeptide

2 of 3

3.13

1.28

0.0050

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

5 of 22

2.66

4.83

6.16e-10

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