Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

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Textmining

[Homology]

Score

ENSONIG00000005212

TSC22 domain family, member 3 (150 aa)

Predicted Functional Partners:

sgk1

0.649

SGK3

0.600

ENSONIG00000004221

0.599

wbscr22

0.505

CCDC69

0.471

pgp

0.470

trmt11

0.435

ENSONIG00000005062

0.435

n6amt1

0.435

ENSONIG00000013703

0.402

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Oreochromis niloticus, Tilapia nilotica

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TSV: tab separated values - can be opened in Excel

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC69	ENSONIG00000005212	ENSONIP00000005438	ENSONIP00000006545	Uncharacterized protein; Coiled-coil domain containing 69	TSC22 domain family, member 3	0.471
ENSONIG00000004221	ENSONIG00000005212	ENSONIP00000005312	ENSONIP00000006545	Peptidylprolyl isomerase; FK506 binding protein 5	TSC22 domain family, member 3	0.599
ENSONIG00000004221	sgk1	ENSONIP00000005312	ENSONIP00000000573	Peptidylprolyl isomerase; FK506 binding protein 5	Serum/glucocorticoid regulated kinase 1	0.545
ENSONIG00000005062	ENSONIG00000005212	ENSONIP00000006366	ENSONIP00000006545	AlkB homolog 8, tRNA methyltransferase; alkB, alkylation repair homolog 8 (E. coli)	TSC22 domain family, member 3	0.435
ENSONIG00000005062	n6amt1	ENSONIP00000006366	ENSONIP00000002353	AlkB homolog 8, tRNA methyltransferase; alkB, alkylation repair homolog 8 (E. coli)	N-6 adenine-specific DNA methyltransferase 1 (putative)	0.848
ENSONIG00000005062	trmt11	ENSONIP00000006366	ENSONIP00000009101	AlkB homolog 8, tRNA methyltransferase; alkB, alkylation repair homolog 8 (E. coli)	tRNA methyltransferase 11 homolog (S. cerevisiae)	0.791
ENSONIG00000005062	wbscr22	ENSONIP00000006366	ENSONIP00000004784	AlkB homolog 8, tRNA methyltransferase; alkB, alkylation repair homolog 8 (E. coli)	BUD23, rRNA methyltransferase and ribosome maturation factor; Williams Beuren syndrome chromosome region 22	0.802
ENSONIG00000005212	CCDC69	ENSONIP00000006545	ENSONIP00000005438	TSC22 domain family, member 3	Uncharacterized protein; Coiled-coil domain containing 69	0.471
ENSONIG00000005212	ENSONIG00000004221	ENSONIP00000006545	ENSONIP00000005312	TSC22 domain family, member 3	Peptidylprolyl isomerase; FK506 binding protein 5	0.599
ENSONIG00000005212	ENSONIG00000005062	ENSONIP00000006545	ENSONIP00000006366	TSC22 domain family, member 3	AlkB homolog 8, tRNA methyltransferase; alkB, alkylation repair homolog 8 (E. coli)	0.435
ENSONIG00000005212	ENSONIG00000013703	ENSONIP00000006545	ENSONIP00000017242	TSC22 domain family, member 3	Si-ch211-195b13.1	0.402
ENSONIG00000005212	SGK3	ENSONIP00000006545	ENSONIP00000017842	TSC22 domain family, member 3	Serum/glucocorticoid regulated kinase family, member 3	0.600
ENSONIG00000005212	n6amt1	ENSONIP00000006545	ENSONIP00000002353	TSC22 domain family, member 3	N-6 adenine-specific DNA methyltransferase 1 (putative)	0.435
ENSONIG00000005212	pgp	ENSONIP00000006545	ENSONIP00000024913	TSC22 domain family, member 3	Phosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily	0.470
ENSONIG00000005212	sgk1	ENSONIP00000006545	ENSONIP00000000573	TSC22 domain family, member 3	Serum/glucocorticoid regulated kinase 1	0.649
ENSONIG00000005212	trmt11	ENSONIP00000006545	ENSONIP00000009101	TSC22 domain family, member 3	tRNA methyltransferase 11 homolog (S. cerevisiae)	0.435
ENSONIG00000005212	wbscr22	ENSONIP00000006545	ENSONIP00000004784	TSC22 domain family, member 3	BUD23, rRNA methyltransferase and ribosome maturation factor; Williams Beuren syndrome chromosome region 22	0.505
ENSONIG00000013703	ENSONIG00000005212	ENSONIP00000017242	ENSONIP00000006545	Si-ch211-195b13.1	TSC22 domain family, member 3	0.402
ENSONIG00000013703	SGK3	ENSONIP00000017242	ENSONIP00000017842	Si-ch211-195b13.1	Serum/glucocorticoid regulated kinase family, member 3	0.474
ENSONIG00000013703	sgk1	ENSONIP00000017242	ENSONIP00000000573	Si-ch211-195b13.1	Serum/glucocorticoid regulated kinase 1	0.943

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