node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhaB | ftsQ | Rv0019c | Rv2151c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Possible cell division protein FtsQ; Essential cell division protein. | 0.501 |
fhaB | ftsW | Rv0019c | Rv2154c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | FtsW-like protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.627 |
fhaB | pbpA | Rv0019c | Rv0016c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family. | 0.967 |
fhaB | pknA | Rv0019c | Rv0015c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibitio [...] | 0.979 |
fhaB | pknB | Rv0019c | Rv0014c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates th [...] | 0.991 |
fhaB | ponA2 | Rv0019c | Rv3682 | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | PASTA domain-containing protein; Rv3682, (MTV025.030), len: 810 aa. Probable ponA2,penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase and transpeptidase activities. Almost identical to Q9CB85|PON1|ML2308 penicillin binding protein (class A) from Mycobacterium leprae (803 aa) FASTA scores: opt: 4743,E(): 3.3e-217, (87.7% identity in 806 aa overlap); or P72351|PON1|PBP1 high-molecular-mass class a penicillin binding protein from Mycobacterium leprae Cosmid B577 (821 aa), FASTA scores: opt: 4547, E(): 6.3e-208, (88.05% identity in 769 aa ov [...] | 0.496 |
fhaB | pstP | Rv0019c | Rv0018c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Phosphoserine/threonine phosphatase PstP; The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (PknA, PknB, PknD, PknE and PknF) and the penicillin-binding protein PBPA. | 0.988 |
fhaB | rodA | Rv0019c | Rv0017c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Probable cell division protein RodA; Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein. Belongs to the FTSW/RODA/SPOVE family. | 0.933 |
fhaB | wag31 | Rv0019c | Rv2145c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Diviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. | 0.604 |
ftsQ | fhaB | Rv2151c | Rv0019c | Possible cell division protein FtsQ; Essential cell division protein. | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | 0.501 |
ftsQ | ftsW | Rv2151c | Rv2154c | Possible cell division protein FtsQ; Essential cell division protein. | FtsW-like protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.999 |
ftsQ | pbpA | Rv2151c | Rv0016c | Possible cell division protein FtsQ; Essential cell division protein. | Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family. | 0.968 |
ftsQ | pbpB | Rv2151c | Rv2163c | Possible cell division protein FtsQ; Essential cell division protein. | Probable penicillin-binding membrane protein PbpB; Synthesis of cross-linked peptidoglycan from the lipid intermediates; Belongs to the transpeptidase family. | 0.994 |
ftsQ | pknA | Rv2151c | Rv0015c | Possible cell division protein FtsQ; Essential cell division protein. | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibitio [...] | 0.591 |
ftsQ | pknB | Rv2151c | Rv0014c | Possible cell division protein FtsQ; Essential cell division protein. | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates th [...] | 0.670 |
ftsQ | ponA2 | Rv2151c | Rv3682 | Possible cell division protein FtsQ; Essential cell division protein. | PASTA domain-containing protein; Rv3682, (MTV025.030), len: 810 aa. Probable ponA2,penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase and transpeptidase activities. Almost identical to Q9CB85|PON1|ML2308 penicillin binding protein (class A) from Mycobacterium leprae (803 aa) FASTA scores: opt: 4743,E(): 3.3e-217, (87.7% identity in 806 aa overlap); or P72351|PON1|PBP1 high-molecular-mass class a penicillin binding protein from Mycobacterium leprae Cosmid B577 (821 aa), FASTA scores: opt: 4547, E(): 6.3e-208, (88.05% identity in 769 aa ov [...] | 0.569 |
ftsQ | pstP | Rv2151c | Rv0018c | Possible cell division protein FtsQ; Essential cell division protein. | Phosphoserine/threonine phosphatase PstP; The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (PknA, PknB, PknD, PknE and PknF) and the penicillin-binding protein PBPA. | 0.487 |
ftsQ | rodA | Rv2151c | Rv0017c | Possible cell division protein FtsQ; Essential cell division protein. | Probable cell division protein RodA; Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein. Belongs to the FTSW/RODA/SPOVE family. | 0.970 |
ftsQ | wag31 | Rv2151c | Rv2145c | Possible cell division protein FtsQ; Essential cell division protein. | Diviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. | 0.970 |
ftsW | fhaB | Rv2154c | Rv0019c | FtsW-like protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | 0.627 |