node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhaA | fhaB | Rv0020c | Rv0019c | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | 0.981 |
fhaA | pbpA | Rv0020c | Rv0016c | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family. | 0.916 |
fhaA | pknA | Rv0020c | Rv0015c | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibitio [...] | 0.970 |
fhaA | pknB | Rv0020c | Rv0014c | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates th [...] | 0.996 |
fhaA | pknD | Rv0020c | Rv0931c | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Transmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D); Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endothelia, but not macrophages, lung epithelia or other endothelia. Phosphorylates the anti-anti-sigma factor homolog Rv0516c, which inhibits binding of Rv0516c to Rv2638, another anti-anti-sigma factor. Can also phosphorylate the FHA domain of Rv1747. | 0.763 |
fhaA | pknE | Rv0020c | Rv1743 | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E); Important for survival of the bacterium in the host during infection. Promotes the survival of infected macrophages by activating multiple signaling responses and suppressing apoptosis of macrophages during nitrate stress. May contribute to the adaptation of M.tuberculosis during stress conditions by maintaining the cellular integrity. Can phosphorylate the FHA domain of Rv1747. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.777 |
fhaA | pknL | Rv0020c | Rv2176 | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L); Phosphorylates the DNA-binding protein Rv2175c. May be involved in the regulation of cell division and cell envelope biosynthesis. | 0.659 |
fhaA | pstP | Rv0020c | Rv0018c | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Phosphoserine/threonine phosphatase PstP; The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (PknA, PknB, PknD, PknE and PknF) and the penicillin-binding protein PBPA. | 0.960 |
fhaA | rodA | Rv0020c | Rv0017c | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | Probable cell division protein RodA; Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein. Belongs to the FTSW/RODA/SPOVE family. | 0.885 |
fhaB | fhaA | Rv0019c | Rv0020c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Conserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. | 0.981 |
fhaB | pbpA | Rv0019c | Rv0016c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family. | 0.967 |
fhaB | pknA | Rv0019c | Rv0015c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibitio [...] | 0.979 |
fhaB | pknB | Rv0019c | Rv0014c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates th [...] | 0.991 |
fhaB | pknD | Rv0019c | Rv0931c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Transmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D); Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endothelia, but not macrophages, lung epithelia or other endothelia. Phosphorylates the anti-anti-sigma factor homolog Rv0516c, which inhibits binding of Rv0516c to Rv2638, another anti-anti-sigma factor. Can also phosphorylate the FHA domain of Rv1747. | 0.588 |
fhaB | pknE | Rv0019c | Rv1743 | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E); Important for survival of the bacterium in the host during infection. Promotes the survival of infected macrophages by activating multiple signaling responses and suppressing apoptosis of macrophages during nitrate stress. May contribute to the adaptation of M.tuberculosis during stress conditions by maintaining the cellular integrity. Can phosphorylate the FHA domain of Rv1747. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.601 |
fhaB | pknL | Rv0019c | Rv2176 | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L); Phosphorylates the DNA-binding protein Rv2175c. May be involved in the regulation of cell division and cell envelope biosynthesis. | 0.748 |
fhaB | pstP | Rv0019c | Rv0018c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Phosphoserine/threonine phosphatase PstP; The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (PknA, PknB, PknD, PknE and PknF) and the penicillin-binding protein PBPA. | 0.988 |
fhaB | rodA | Rv0019c | Rv0017c | Conserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. | Probable cell division protein RodA; Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein. Belongs to the FTSW/RODA/SPOVE family. | 0.933 |
fmu | pknB | Rv1407 | Rv0014c | Probable Fmu protein (sun protein); May act as RNA methyltransferase. | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates th [...] | 0.719 |
fmu | pstP | Rv1407 | Rv0018c | Probable Fmu protein (sun protein); May act as RNA methyltransferase. | Phosphoserine/threonine phosphatase PstP; The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (PknA, PknB, PknD, PknE and PknF) and the penicillin-binding protein PBPA. | 0.942 |