node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0059 | Rv0060 | Rv0059 | Rv0060 | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | 0.989 |
Rv0059 | Rv0837c | Rv0059 | Rv0837c | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Hypothetical protein; Rv0837c, (MTV043.30c), len: 342 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.620 |
Rv0059 | Rv0909 | Rv0059 | Rv0909 | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0910. | 0.457 |
Rv0059 | Rv1044 | Rv0059 | Rv1044 | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Rv1044, (MTCY10G2.05c), len: 207 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.656 |
Rv0059 | Rv1545 | Rv0059 | Rv1545 | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Hypothetical protein; Rv1545, (MTCY48.20), len: 75 aa. Hypothetical unknown protein. | 0.444 |
Rv0059 | Rv1546 | Rv0059 | Rv1546 | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Conserved protein; Rv1546, (MTCY48.19c), len: 143 aa. Conserved protein, similar to O05902|Rv0910|MTCY21C12.04 Hypothetical protein from Mycobacterium tuberculosis (144 aa), FASTA scores: E(): 5e-30, (37.3% identity in 142 aa overlap). | 0.484 |
Rv0059 | dnaB | Rv0059 | Rv0058 | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Probable replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; Belongs to the helicase family. DnaB subfamily. | 0.856 |
Rv0059 | mbcT | Rv0059 | Rv1989c | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Neutralized by cognate antitoxin MbcA. Degrades NAD(+) by phosphorolysis. Expression in the absence of its cognate antitoxin MbcA causes dramatic reduction of intracellular NAD(+) levels and is deleterious to cell growth, causing cell death. In a SCID mouse infection model, mice infected with bacteria overexpressing this protein survive longer. Overexpression of this protein in a mouse infection model at 21 days leads to bacterial death, and shows a synergistic 100-fold increase in mouse survival when combi [...] | 0.651 |
Rv0060 | Rv0059 | Rv0060 | Rv0059 | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein. | 0.989 |
Rv0060 | Rv0272c | Rv0060 | Rv0272c | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Unknown protein; Rv0272c, (MTCY06A4.16c), len: 377 aa. Unknown protein. | 0.804 |
Rv0060 | Rv0837c | Rv0060 | Rv0837c | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Hypothetical protein; Rv0837c, (MTV043.30c), len: 342 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.516 |
Rv0060 | Rv0909 | Rv0060 | Rv0909 | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0910. | 0.532 |
Rv0060 | Rv1044 | Rv0060 | Rv1044 | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Rv1044, (MTCY10G2.05c), len: 207 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.803 |
Rv0060 | Rv1545 | Rv0060 | Rv1545 | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Hypothetical protein; Rv1545, (MTCY48.20), len: 75 aa. Hypothetical unknown protein. | 0.515 |
Rv0060 | Rv1546 | Rv0060 | Rv1546 | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Conserved protein; Rv1546, (MTCY48.19c), len: 143 aa. Conserved protein, similar to O05902|Rv0910|MTCY21C12.04 Hypothetical protein from Mycobacterium tuberculosis (144 aa), FASTA scores: E(): 5e-30, (37.3% identity in 142 aa overlap). | 0.527 |
Rv0060 | dnaB | Rv0060 | Rv0058 | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Probable replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; Belongs to the helicase family. DnaB subfamily. | 0.530 |
Rv0060 | mbcT | Rv0060 | Rv1989c | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Neutralized by cognate antitoxin MbcA. Degrades NAD(+) by phosphorolysis. Expression in the absence of its cognate antitoxin MbcA causes dramatic reduction of intracellular NAD(+) levels and is deleterious to cell growth, causing cell death. In a SCID mouse infection model, mice infected with bacteria overexpressing this protein survive longer. Overexpression of this protein in a mouse infection model at 21 days leads to bacterial death, and shows a synergistic 100-fold increase in mouse survival when combi [...] | 0.660 |
Rv0060 | phoH1 | Rv0060 | Rv2368c | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | Rv2368c, (MTCY27.12), len: 352 aa. Probable phoH1,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein, equivalent to Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-like protein from Mycobacterium leprae (349 aa), FASTA scores: opt: 1952, E(): 4.7e-107, (88.9% identity in 352 aa overlap). Also highly similar to Q9L2L5|SCC117.05 PHOH-like protein from Streptomyces coelicolor (359 aa), FASTA scores: opt: 1407, E(): 3.6e-75, (63.6% identity in 349 aa overlap); Q9RSY1|DR1988 PHOH-related protein from Deinococcus radiodurans (380 aa), FASTA scores: opt: 1053, E( [...] | 0.810 |
Rv0272c | Rv0060 | Rv0272c | Rv0060 | Unknown protein; Rv0272c, (MTCY06A4.16c), len: 377 aa. Unknown protein. | Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein. | 0.804 |
Rv0272c | phoH1 | Rv0272c | Rv2368c | Unknown protein; Rv0272c, (MTCY06A4.16c), len: 377 aa. Unknown protein. | Rv2368c, (MTCY27.12), len: 352 aa. Probable phoH1,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein, equivalent to Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-like protein from Mycobacterium leprae (349 aa), FASTA scores: opt: 1952, E(): 4.7e-107, (88.9% identity in 352 aa overlap). Also highly similar to Q9L2L5|SCC117.05 PHOH-like protein from Streptomyces coelicolor (359 aa), FASTA scores: opt: 1407, E(): 3.6e-75, (63.6% identity in 349 aa overlap); Q9RSY1|DR1988 PHOH-related protein from Deinococcus radiodurans (380 aa), FASTA scores: opt: 1053, E( [...] | 0.871 |