node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PPE4 | Rv0281 | Rv0286 | Rv0281 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | 0.581 |
PPE4 | eccA3 | Rv0286 | Rv0282 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | 0.929 |
PPE4 | eccB3 | Rv0286 | Rv0283 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | 0.962 |
PPE4 | eccC3 | Rv0286 | Rv0284 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.968 |
PPE4 | eccD3 | Rv0286 | Rv0290 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.936 |
PPE4 | eccE3 | Rv0286 | Rv0292 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX-3 secretion system protein EccE3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. Belongs to the EccE family. | 0.933 |
PPE4 | espG3 | Rv0286 | Rv0289 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX-3 secretion-associated protein EspG3; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. | 0.954 |
PPE4 | mycP3 | Rv0286 | Rv0291 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | Mycosin-3; Rv0291, (MTV035.19), len: 461 aa. Probable mycP3,membrane-anchored serine protease (mycosin) (see Brown et al., 2000), similar to several others in mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from Mycobacterium leprae (446 aa), FASTA scores: opt: 1159, E(): 0, (43.5 identity in 446 aa overlap). Has signal sequence and hydrophobic stretch at C-terminus, followed by short positively charged segment,that seems t [...] | 0.904 |
Rv0281 | PPE4 | Rv0281 | Rv0286 | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | 0.581 |
Rv0281 | eccA3 | Rv0281 | Rv0282 | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | 0.916 |
Rv0281 | eccB3 | Rv0281 | Rv0283 | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | 0.901 |
Rv0281 | eccC3 | Rv0281 | Rv0284 | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.916 |
Rv0281 | eccD3 | Rv0281 | Rv0290 | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.534 |
Rv0281 | espG3 | Rv0281 | Rv0289 | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | ESX-3 secretion-associated protein EspG3; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. | 0.426 |
Rv0281 | mycP3 | Rv0281 | Rv0291 | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | Mycosin-3; Rv0291, (MTV035.19), len: 461 aa. Probable mycP3,membrane-anchored serine protease (mycosin) (see Brown et al., 2000), similar to several others in mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from Mycobacterium leprae (446 aa), FASTA scores: opt: 1159, E(): 0, (43.5 identity in 446 aa overlap). Has signal sequence and hydrophobic stretch at C-terminus, followed by short positively charged segment,that seems t [...] | 0.439 |
eccA3 | PPE4 | Rv0282 | Rv0286 | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | 0.929 |
eccA3 | Rv0281 | Rv0282 | Rv0281 | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | 0.916 |
eccA3 | eccB3 | Rv0282 | Rv0283 | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | 0.995 |
eccA3 | eccB5 | Rv0282 | Rv1782 | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | 0.579 |
eccA3 | eccC3 | Rv0282 | Rv0284 | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.994 |