node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PE35 | PE5 | Rv3872 | Rv0285 | PE family-related protein PE35; Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2). | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | 0.664 |
PE35 | PPE4 | Rv3872 | Rv0286 | PE family-related protein PE35; Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2). | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | 0.651 |
PE5 | PE35 | Rv0285 | Rv3872 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | PE family-related protein PE35; Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2). | 0.664 |
PE5 | PPE37 | Rv0285 | Rv2123 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below). | 0.843 |
PE5 | PPE4 | Rv0285 | Rv0286 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | 0.990 |
PE5 | eccA3 | Rv0285 | Rv0282 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | 0.894 |
PE5 | eccB3 | Rv0285 | Rv0283 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | 0.924 |
PE5 | eccC3 | Rv0285 | Rv0284 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.881 |
PE5 | eccD3 | Rv0285 | Rv0290 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.671 |
PE5 | espG3 | Rv0285 | Rv0289 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | ESX-3 secretion-associated protein EspG3; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. | 0.715 |
PE5 | esxG | Rv0285 | Rv0287 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | ESAT-6 like protein EsxG (conserved protein TB9.8); EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol. | 0.912 |
PE5 | esxH | Rv0285 | Rv0288 | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4); EsxH, in complex with EsxG, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. Belongs to the WXG100 family. ESAT-6 subfamily. | 0.854 |
PPE37 | PE5 | Rv2123 | Rv0285 | Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below). | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | 0.843 |
PPE37 | eccB3 | Rv2123 | Rv0283 | Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below). | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | 0.482 |
PPE37 | eccD3 | Rv2123 | Rv0290 | Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below). | ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.497 |
PPE37 | esxG | Rv2123 | Rv0287 | Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below). | ESAT-6 like protein EsxG (conserved protein TB9.8); EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol. | 0.483 |
PPE4 | PE35 | Rv0286 | Rv3872 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | PE family-related protein PE35; Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2). | 0.651 |
PPE4 | PE5 | Rv0286 | Rv0285 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. | 0.990 |
PPE4 | eccA3 | Rv0286 | Rv0282 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). Belongs to the CbxX/CfxQ family. | 0.929 |
PPE4 | eccB3 | Rv0286 | Rv0283 | PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family. | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | 0.962 |